Synchrotron X-ray analyses demonstrate phosphate-bound gadolinium in skin in nephrogenic systemic fibrosis
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چکیده
منابع مشابه
Synchrotron X-ray analyses demonstrate phosphate-bound gadolinium in skin in nephrogenic systemic fibrosis.
BACKGROUND Nephrogenic systemic fibrosis (NSF) is an incurable, debilitating disease found exclusively in patients with decreased kidney function and comprises a fibrosing disorder of the skin and systemic tissues. The disease is associated with exposure to gadolinium (Gd)-based contrast agents (GBCA) used in magnetic resonance imaging (MRI). Tissue samples from many patients with NSF contain m...
متن کاملSynchrotron X-ray Analysis Demonstrate Phosphate-Bound Gadolinium in Skin in Nephrogenic Systemic Fibrosis
Figure 1. Light and synchrotron x-ray fluorescence (SXRF) microscopy images of the skin tissue showing element distribution. (a) Light microscopy; haematoxylin and eosin (H&E)-stained section of skin with dense fibrosis involving the dermis, extending into the subcutaneous tissue and containing areas of fibrocytes, osteoclast-like giant cells and tissue calcification. (b–g) Images of the tissue...
متن کاملGadolinium-associated nephrogenic systemic fibrosis.
Nephrogenic systemic fibrosis is a progressive, potentially fatal multiorgan system fibrosing disease related to exposure of patients with renal failure to the gadolinium-based contrast agents used in magnetic resonance imaging. Because of this relationship between nephrogenic systemic fibrosis and gadolinium-based contrast agents, the U.S. Food and Drug Administration currently warns against u...
متن کاملGadolinium chelate-associated nephrogenic systemic fibrosis.
Correspondence to: Dr Kei Pin Lin Tel: (65) 6222 3322 Fax: (65) 6326 5242 Email: binglin8@ yahoo.com.sg Nephrogenic systemic fibrosis (NSF) is a rare multisystem disease characterised by widespread tissue fibrosis. It is recognised for its epidemiological association in patients with chronic renal failure, after administration of gadolinium-chelate magnetic resonance (MR) contrast agent, partic...
متن کاملNephrogenic systemic fibrosis following gadolinium administration.
To the Editor: Nephrogenic systemic fibrosis (NSF) is an emerging medical entity in patients with renal disease, which results in progressive cutaneous and systemic fibrosis. It is a rare disorder that has been recognized in patients with renal impairment since 2000.1 Patients with NSF demonstrate symmetric dermal and subcutaneous fibrosis evidenced by increasing skin induration on clinical exa...
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ژورنال
عنوان ژورنال: British Journal of Dermatology
سال: 2010
ISSN: 0007-0963
DOI: 10.1111/j.1365-2133.2010.09918.x